In aged mice, Argireline applied twice daily for 6 weeks improved skin structure and increased type I collagen (the stronger, more supportive kind) by a statistically significant amount. Type III collagen decreased, which suggests a shift toward better-quality collagen. The study shows Argireline can work on a cellular level, not just temporarily plump wrinkles.

Researchers applied Argireline to artificially aged mice for 6 weeks, then examined skin tissue under a microscope using special stains to measure collagen types and overall structure.

Funding not disclosed in abstract