Review
Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway.
Xiaotian Xu, Yuhui Wang, Zhifeng Wei, Wenhui Wei, Peng Zhao, Bei Tong + 2 more
ReviewCell death & disease2017
Research Facts
Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway.
Xiaotian Xu, Yuhui Wang, Zhifeng Wei, Wenhui Wei, Peng Zhao, Bei Tong + 2 more
Review · Moderate · 2017
Findings

Madecassic acid (a compound from Centella asiatica) reduced inflammatory markers in mice with colitis by shifting immune cells away from inflammation-promoting Th17 cells toward calming Treg cells. When given orally, it decreased inflammatory proteins like IL-17A and IL-17F while increasing anti-inflammatory IL-10. This worked through a specific cellular pathway (PPARγ/AMPK), but the study was done in mice—we don't have human skin or gut data yet.

Design
Review
Evidence
Moderate
Journal
Cell death & disease
Methodology

Researchers tested four triterpenoid compounds from Centella asiatica in mice with colitis, identified madecassic acid as the most effective, and then traced exactly which cellular pathways and proteins it activates or deactivates.

Funded By

Funding not disclosed in abstract