Review
Insulin-like growth factor-binding protein-7 (IGFBP7) links senescence to heart failure.
Liyong Zhang, David Smyth, Mohammad Al-Khalaf, Alice Blet, Qiujiang Du, Jordan Bernick + 13 more
ReviewNature cardiovascular research2022
Research Facts
Insulin-like growth factor-binding protein-7 (IGFBP7) links senescence to heart failure.
Liyong Zhang, David Smyth, Mohammad Al-Khalaf, Alice Blet, Qiujiang Du, Jordan Bernick + 13 more
Review · Moderate · 2022
Findings

Researchers found that a protein called IGFBP7 is significantly elevated in heart failure patients and contributes to aging of heart cells. When they blocked IGFBP7 in mice with heart disease, cardiac function improved, inflammation decreased, and cells showed better ability to repair DNA damage and neutralize harmful free radicals.

Design
Review
Evidence
Moderate
Journal
Nature cardiovascular research
Methodology

Scientists studied heart tissue and blood samples from heart failure patients, then used mouse models of heart disease to test whether removing or neutralizing IGFBP7 could improve outcomes.

Funded By

Funding not disclosed in abstract