2-Amino-6-Chloro-4-Nitrophenol Hydrochloride
AKA “CCRIS 4578, Phenol, monohydrochloride, hydrochloride (1:1), EINECS 263-645-9, 2-Amino-6-chloro-4-nitrophenol monohydrochloride, UNII-B7934OT74Q”
Synthetic
Ingredient Facts
2-amino-6-chloro-4-nitrophenol hydrochloride
AKA: CCRIS 4578, Monohydrochloride, Hydrochloride (1:1), EINECS 263-645-9, 2-Amino-6-chloro-4-nitrophenol monohydrochloride, UNII-B7934OT74Q
Synthetic · Colorant · EWG: 4
Synthetic
Colorant
Synthetic
Clean
A synthetic colorant used in hair dyes to create rich, lasting color. Safe for use in hair formulations at recommended concentrations.
Solubility less than 1 mg/mL at 70.7 °F (NTP, 1992)
Formula
C6H6Cl2N2O3
Mol. Weight
225.03
CAS #
62625-14-3
Form
Powder
State
2-amino-6-chloro-4-nitrophenol hydrochloride appears as a brown powder. (NTP, 1992)
See origin →
Functions
Colorant
Gives the product its color. Purely aesthetic — makes the formula look good in the jar but does nothing for your skin.
Traditional Use
A hydrochloride salt of a synthetic hair dye precursor developed for improved solubility and stability. It was created to enhance performance in permanent hair coloring formulations.
Skin Types
●all-skin-types
Best For
General
Melanin-Rich Skin
Suitable
Pregnancy & Breastfeeding Safe
No
2-Amino-4-nitrophenol.
IARC monographs on the evaluation of carcinogenic risks to humans, 1993
2-Amino-5-nitrophenol.
IARC monographs on the evaluation of carcinogenic risks to humans, 1993
4-amino-2-nitrophenol.
IARC monographs on the evaluation of the carcinogenic risk of chemicals to man, 1978
Polyphenols: skin photoprotection and inhibition of photocarcinogenesis.
Afaq F, Katiyar SK
Mini reviews in medicinal chemistry, 2011
Polyphenols: skin photoprotection and inhibition of photocarcinogenesis.
Afaq F, Katiyar SK
Mini reviews in medicinal chemistry, 2011
Potential skin anti-aging effects of main phenolic compounds, tremulacin and tremuloidin from Salix chaenomeloides leaves on TNF-α-stimulated human de
Ahn SY, Kim KA, Lee S, Kim KH
Chemico-biological interactions, 2024
Efficacy of a topical polyphenol-based formulation in palmoplantar psoriasis: an observational study.
Amato S, Dattola A, Bennardo L, Tolone M, Nisticò SP
Dermatology reports, 2025
Efficacy of a topical polyphenol-based formulation in palmoplantar psoriasis: an observational study.
Amato S, Dattola A, Bennardo L, Tolone M, Nisticò SP
Dermatology reports, 2025
Final report on the safety assessment of amino nitrophenols as used in hair dyes.
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
Final report on the safety assessment of amino nitrophenols as used in hair dyes.
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
Final report on the safety assessment of amino nitrophenols as used in hair dyes.
Burnett CL, Bergfeld WF, Belsito DV, Klaassen CD, Marks JG Jr et al.
International journal of toxicology, 2009
Final Amended Report on the Safety Assessment of p-Methylaminophenol Sulfate and p-Methylaminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 2-Amino-6-Chloro-4-Nitrophenol and 2-Amino-6-Chloro-4-Nitrophenol Hydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 2-Methyl-5-Hydroxyethylaminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 2,4-Diaminophenol and 2,4-Diaminophenol Dihydrochloride
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of 6-Amino-m-Cresol, 6-Amino-o-Cresol, 4-Amino-m-Cresol, 5-Amino-4-Chloro-o-Cresol, 5-Amino-6-Chloro-o-Cresol and 4-Chloro-2-Aminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Amino Nitrophenols Used in Hair Dyes
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of p-Aminophenol, m-Aminophenol, and o-Aminophenol
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of p-Methylaminophenol Sulfate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report on the Safety Assessment of Zinc Phenolsulfonate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report: Amended Safety Assessment of 4-Chloro-2-Aminophenol as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report: Safety Assessment of Sodium Benzotriazolyl Butylphenol Sulfonate as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Final Report: Safety Assessment of Tetrabromophenol Blue as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Zinc Phenolsulfonate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
2-Amino-6-Chloro-4-Nitrophenol
European Commission
EU Cosmetic Ingredient Database (CosIng)
2-Methyl-5-Hydroxyethylaminophenol
European Commission
EU Cosmetic Ingredient Database (CosIng)
3-Nitro-p-Hydroxyethylaminophenol
European Commission
EU Cosmetic Ingredient Database (CosIng)
4-Amino-3-Nitrophenol
European Commission
EU Cosmetic Ingredient Database (CosIng)
4-Hydroxypropylamino-3-Nitrophenol
European Commission
EU Cosmetic Ingredient Database (CosIng)
Sodium Benzotriazolyl Butylphenol Sulfonate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Zinc Phenolsulfonate
European Commission
EU Cosmetic Ingredient Database (CosIng)
Safety and efficacy of l-histidine monohydrochloride monohydrate produced using Corynebacterium glutamicum KCCM 80179 for all animal species.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, de Lourdes Bastos M, Christensen H et al.
EFSA journal. European Food Safety Authority, 2019
Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCC
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, Bastos ML, Christensen H et al.
EFSA journal. European Food Safety Authority, 2020
2-Amino-5-Nitrophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
2-Amino-6-Chloro-4-Nitrophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
2-Methyl-5-Hydroxyethylaminophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
3-Nitro-p-Hydroxyethylaminophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
4-Amino-3-Nitrophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
4-Hydroxypropylamino-3-Nitrophenol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Sodium Benzotriazolyl Butylphenol Sulfonate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Zinc Phenolsulfonate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
2-Amno-6-Chloro-4-Nitrophenol.
Fiume MM
International journal of toxicology, 2017
Novel Bioactive Multifunctional Polyphenols: A Chemo-Enzymatic Approach.
Flourat AL, Thiébault E, Martinez A, Brunissen F, Dosso A et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 2026
2-Amino-1,2-bis(4-methoxyphenol) ethanol and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
2-Amino-4-nitrophenol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
2-Amino-5-nitrophenol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
4-Amino-2-nitrophenol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
4-Benzyloxyphenol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
4-Ethoxyphenol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
4-tert-Butylphenol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
4,4'-Isopropylidenediphenol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Dinitrophenol isomers
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Phenol
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Phenolphthalein
Health Canada
Health Canada Cosmetic Ingredient Hotlist
Occupational allergic contact dermatitis caused by epoxy diacrylate in ultraviolet-light-cured paint, and bisphenol A in dental composite resin.
Jolanki R, Kanerva L, Estlander T
Contact dermatitis, 1995
Effects of antioxidant polyphenols on TNF-alpha-related diseases.
Kawaguchi K, Matsumoto T, Kumazawa Y
Current topics in medicinal chemistry, 2011
Effects of antioxidant polyphenols on TNF-alpha-related diseases.
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Current topics in medicinal chemistry, 2011
Effects of antioxidant polyphenols on TNF-alpha-related diseases.
Kawaguchi K, Matsumoto T, Kumazawa Y
Current topics in medicinal chemistry, 2011
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Scientific reports, 2023
Antioxidant effects of phenolic compounds in through the distillation of Lonicera japonica & Chenpi extract and anti-inflammation on skin keratinocyte
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Scientific reports, 2023
Antioxidant effects of phenolic compounds in through the distillation of Lonicera japonica & Chenpi extract and anti-inflammation on skin keratinocyte
Kim HH, Jeong SH, Park MY, Bhosale PB, Abusaliya A et al.
Scientific reports, 2023
Antioxidant effects of phenolic compounds in through the distillation of Lonicera japonica & Chenpi extract and anti-inflammation on skin keratinocyte
Kim HH, Jeong SH, Park MY, Bhosale PB, Abusaliya A et al.
Scientific reports, 2023
Analytical Method Development and Dermal Absorption of 4-Amino-3-Nitrophenol (4A3NP), a Hair Dye Ingredient under the Oxidative or Non-Oxidative Condi
Kim HY, Kim YJ, Lee JD, Kim HR, Seo DW
Toxics, 2024
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Sargassum horneri extract containing polyphenol alleviates DNCB-induced atopic dermatitis in NC/Nga mice through restoring skin barrier function.
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Journal of visualized experiments : JoVE, 2024
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Myat Win S, Saelee M, Myo H, Khat-Udomkiri N
Journal of visualized experiments : JoVE, 2024
Allergic contact dermatitis due to nonylphenol ethoxylate (nonoxynol-6).
Nethercott JR, Lawrence MJ
Contact dermatitis, 1984
Lingonberry (Vaccinium vitis-idaea L.) Fruit Phenolic Bio...
Pirjo Pärnänen, Sari Niikko, Hanna Lähteenmäki, Ismo T Räisänen, Taina Tervahartiala, Timo Sorsa + 1 more
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Molecules (Basel, Switzerland), 2020
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Journal of agricultural and food chemistry, 2010
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Dermatologic therapy, 2020
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Søsted H, Menné T
Contact dermatitis, 2005
Protective Role of Phenolic Compounds from Whole Cardamom (Elettaria cardamomum (L.) Maton) against LPS-Induced Inflammation in Colon and Macrophage C
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Nutrients, 2023
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International journal of toxicology, 2024
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The Journal of dermatology, 2014
Extraction of Polyphenols and Vitamins Using Biodegradable ATPS Based on Ethyl Lactate.
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Molecules (Basel, Switzerland), 2022
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Food research international (Ottawa, Ont.), 2017
Profiling and quantification of phenolic compounds in Camellia seed oils: Natural tea polyphenols in vegetable oil.
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Food research international (Ottawa, Ont.), 2017
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Žilius M, Ramanauskienė K, Juškaitė V, Briedis V
Evidence-based complementary and alternative medicine : eCAM, 2016
Verified Feb 2026
Data: PubChem · CosIng · EWG · CIR