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Aldioxa
AKA “Isalon, Dihydroxyaluminum allantoinate, Aluminum, ((2, 5-dioxo-4-imidazolidinyl)ureato)dihydroxy-, DTXSID8057774, Chlokale, Peptilate, Aldioxum [INN-Latin], Aldioxa [USAN:INN:JAN], Aldioxum, (allantoinato)dihydroxy-”
Ingredient
Ingredient Facts
Aldioxa
AKA: Isalon, Dihydroxyaluminum allantoinate, Aluminum, ((2, 5-dioxo-4-imidazolidinyl)ureato)dihydroxy-, DTXSID8057774, Chlokale, Peptilate, Aldioxum [INN-Latin], Aldioxa [USAN:INN:JAN], Aldioxum, (allantoinato)dihydroxy-
Ingredient · Antimicrobial · EWG: 3
Synthetic
Preservative
Astringent
Not Clean
Aluminum, [(2,5-dioxo-4-imidazolidinyl)ureato]dihydroxy-
Formula
C4H9AlN4O5
Mol. Weight
220.12
CAS #
5579-81-7
Form
Liquid
See origin →
Functions
Antimicrobial
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Astringent
Tightens and contracts skin tissue, temporarily shrinking pores and reducing oiliness. That "clean, tight" feeling after toner.
Controls excess oil
Fights acne
Causing bacteria
Minimizes pores
Traditional Use
A synthetic antimicrobial compound developed in the 20th century as a preservative. Used in cosmetics to prevent bacterial and fungal contamination in formulations.
Skin Types
●all-skin-types
Best For
General
Pregnancy & Breastfeeding Safe
Caution
EWG
3
CIR
Insufficient data
Pregnancy
Caution
CIR Safety Findings
Not a Sensitizer
all-shades-safe
Regulatory Status
USAunder review
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Aluminum Starch Octenylsuccinate.
Akinsulie A, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2023
→
Aluminum Starch Octenylsuccinate.
Akinsulie A, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2023
→
Aluminum Starch Octenylsuccinate.
Akinsulie A, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2023
→
Aluminum Starch Octenylsuccinate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report of the Safety Assessment of Lithium Stearate, Aluminum Distearate, Aluminum Stearate, Aluminum Tristearate, Ammonium Stearate, Calcium Stearate, Magnesium Stearate, Potassium Stearate, So
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Aldioxa
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Aluminum Silicate, Calcium Silicate, Magnesium Aluminum Silicate, Magnesium Silicate, Magnesium Trisilicate, Sodium Magnesium Silicate, Zirconium Silicate, Att
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Aluminum Starch Octenylsuccinate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Silica, Alumina Magnesium Metasilicate, Aluminum Calcium Sodium Silicate, Aluminum Iron Silicates, Hydrated Silica and Potassium Aluminum Silicate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Alumina and Aluminum Hydroxide as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Aldioxa
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Calcium Sodium Silicate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Citrate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Dilinoleate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Dimyristate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Distearate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Iron Calcium Magnesium Germanium Silicates
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Iron Calcium Magnesium Zirconium Silicates
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Iron Silicates
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Isostearate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Isostearates/Laurates/Palmitates
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Isostearates/Laurates/Stearates
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Isostearates/Myristates
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Isostearates/Palmitates
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Isostearates/Stearates
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Lanolate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Myristate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Myristates/Palmitates
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Silicate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Stearate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Stearates
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Aluminum Tristearate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Ammonium Silver Zinc Aluminum Silicate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Magnesium Aluminum Silicate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Potassium Aluminum Polyacrylate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Sodium Potassium Aluminum Silicate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Sodium Silver Aluminum Silicate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Bioavailability and intestinal absorption of aluminum in rats: effects of aluminum compounds and some dietary constituents.
Cunat L, Lanhers MC, Joyeux M, Burnel D
Biological trace element research, 2000
→
Aluminum and Breast Cancer Hypothesis
Darbre PD
Journal of Inorganic Biochemistry, 2005
→
Final report on the safety assessment of aluminum silicat...
Amy R Elmore
International journal of toxicology, 2003
→
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate,
Elmore AR, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2003
→
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate,
Elmore AR, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2003
→
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate,
Elmore AR, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2003
→
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate,
Elmore AR, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2003
→
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate,
Elmore AR, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2003
→
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate,
Elmore AR, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2003
→
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate,
Elmore AR, Cosmetic Ingredient Review Expert Panel
International journal of toxicology, 2003
→
Aluminum Calcium Sodium Silicate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Aluminum Dimyristate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Aluminum Distearate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Aluminum Hydroxide
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Aluminum Myristate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Aluminum Myristates/Palmitates
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Aluminum Silicate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Aluminum Starch Octenylsuccinate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Aluminum Stearate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Aluminum Tristearate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Calcium Aluminum Borosilicate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Magnesium Aluminum Silicate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Sodium Potassium Aluminum Silicate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Sodium Silver Aluminum Silicate
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Dietary unsaponifiable fraction of extra virgin olive oil supplementation attenuates lung injury and DNA damage of rats co-exposed to aluminum and acr
Ghorbel I, Chaâbane M, Boudawara O, Kamoun NG, Boudawara T et al.
Environmental science and pollution research international, 2016
→
Aluminum chloride
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Aluminum chlorohydrate and its associated complexes
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Aluminum zirconium complexes
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
b) Not permitted in combination with aluminum chloride, aluminum chlorohydrate or its associated complexes or other aluminum zirconium complexes.
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
b) Not permitted in combination with aluminum chlorohydrate or its associated complexes or aluminum zirconium complexes
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
c) Deodorants and antiperspirants containing aluminum chloride must be in the form of an aqueous solution.
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Review of aluminum, paraben, and sulfate product disclaimers on personal care products.
Liszewski W, Zaidi AJ, Fournier E, Scheman A
Journal of the American Academy of Dermatology, 2022
→
Studies of prophylaxis pastes containing sodium-potassium aluminum silicate and fluoride.
Putt MS, Kleber CJ, Muhler JC
Journal of dental research, 1979
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR