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Butyl Glycolate
AKA “butyl 2-hydroxyacetate, 7397-62-8, Butyl hydroxyacetate, Acetic acid, hydroxy-, butyl ester, n-butyl glycolate, UNII-3H5QAS0HZX, 3H5QAS0HZX, Glycolic acid, 2-hydroxy-”
Skin Conditioning
Ingredient Facts
Butyl glycolate
AKA: Butyl 2-hydroxyacetate, 7397-62-8, Butyl hydroxyacetate, Acetic acid, Hydroxy-, Butyl ester, N-butyl glycolate, UNII-3H5QAS0HZX, 3H5QAS0HZX, Glycolic acid, 2-hydroxy-
Skin Conditioning · Skin Conditioning · EWG: 4
Synthetic
Skin Conditioner
Chemical Exfoliant
Not Clean
Acetic acid, 2-hydroxy-, butyl ester,Butyl hydroxyacetate
Formula
C6H12O3
Mol. Weight
132.16
CAS #
7397-62-8
Form
Liquid
State
Liquid
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Locks in moisture
Traditional Use
Synthetic exfoliating agent developed in the late 20th century as a milder alternative to glycolic acid. Designed to provide gentle chemical exfoliation with reduced irritation in skincare products.
Skin Types
●all-skin-types
Best For
Uneven Texture
Pregnancy & Breastfeeding Safe
Caution
EWG
4
CIR
Safe as used
Pregnancy
Caution
CIR Safety Findings
medical-approval
all-shades-safe
Mild Irritant
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics.
Burnett CL, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
→
Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics.
Burnett CL, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2025
→
HPLC determination of thioglycolic acid and other aliphatic thiols in cosmetic formulations using ethacrynic acid as precolumn derivatization reagent.
Cavrini V, Andrisano V, Gatti R, Scapini G
International journal of cosmetic science, 1990
→
Sodium Dehydroacetate and Dehydroacetic Acid.
Cherian P, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2024
→
Sodium Dehydroacetate and Dehydroacetic Acid.
Cherian P, Bergfeld WF, Belsito DV, Cohen DE, Klaassen CD et al.
International journal of toxicology, 2024
→
Final Report on the Safety Assessment of Ammonium and Glyceryl Thioglycolates and Thioglycolic Acid
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Ethyl Ester of PVM/MA Copolymer and Butyl Ester of PVM/MA Copolymer
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Glycolic Acid, Ammonium, Calcium, Potassium, and Sodium Glycolates, Methyl, Ethyl, Propyl, and Butyl Glycolates, and Lactic Acid, Ammonium, Calcium, Potassium,
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Final Report on the Safety Assessment of Sodium Dehydroacetate and Dehydroacetic Acid
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Sodium Dehydroacetate and Dehydroacetic Acid
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Acetic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Beta-Alanine Diacetic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Butyl Ester of PVM/MA Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Butyl Glycolate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
dehydroacetic acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Glycolic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Potassium Butyl Ester of PVM/MA Copolymer
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Thioglycolic Acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Acetic acid and the skin: a review of vinegar in dermatology.
Elhage KG, St Claire K, Daveluy S
International journal of dermatology, 2022
→
Acetic acid and the skin: a review of vinegar in dermatology.
Elhage KG, St Claire K, Daveluy S
International journal of dermatology, 2022
→
Acetic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Butyl Ester of PVM/MA Copolymer
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
dehydroacetic acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Glycolic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Thioglycolic Acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Potential application of novel liquid crystal nanoparticles of isostearyl glyceryl ether for transdermal delivery of 4-biphenyl acetic acid.
Fujii MY, Asakawa Y, Fukami T
International journal of pharmaceutics, 2020
→
Preparation of (13)C-labeled ceramide by acetic acid bacteria and its incorporation in mice.
Fukami H, Tachimoto H, Kishi M, Kaga T, Waki H et al.
Journal of lipid research, 2010
→
2,4-Dihydroxy-3-methylbenzaldehyde
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
4,4'-Dihydroxy-3,3'-(3-methylthiopropylidene) dicoumarin
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Glycolic acid
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Thioglycolic acid and its salts
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Thioglycolic acid esters
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Toluidines, their isomers, salts and halogenated and sulfonated derivatives except 4-hydroxy-2-nitro-toluidine and hydroxyethyl-2-nitro-p-toluidine
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Trichloroacetic acid
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
RALGA (Diacneal), a retinaldehyde and glycolic acid assoc...
A D Katsambas
Dermatology (Basel, Switzerland), 2005
→
Effects of 1 alpha,25-dihydroxy-vitamin D3 and calcipotriol on organotypic cultures of outer root sheath cells: a potential model to evaluate antipsor
Limat A, Hunziker T, Braathen LR
Archives of dermatological research, 1993
→
The use of glycolic acid as a peeling agent.
H Murad, A T Shamban, P S Premo
Dermatologic clinics, 1995
→
Pd/C-Catalyzed Efficient and Selective Synthesis of Glycolic Acid from Ethylene Glycol.
Schmoll A, Huo YW, Shao S, Wu XF
ChemSusChem, 2025
→
Nobiletin and 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone Ameliorate 12- O-Tetradecanoylphorbol-13-acetate-Induced Psoriasis-Like Mouse Skin Lesions by
Yang G, Li S, Yang Y, Yuan L, Wang P et al.
Journal of agricultural and food chemistry, 2018
→
Nobiletin and 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone Ameliorate 12- O-Tetradecanoylphorbol-13-acetate-Induced Psoriasis-Like Mouse Skin Lesions by
Yang G, Li S, Yang Y, Yuan L, Wang P et al.
Journal of agricultural and food chemistry, 2018
→
Nobiletin and 5-Hydroxy-6,7,8,3',4'-pentamethoxyflavone Ameliorate 12- O-Tetradecanoylphorbol-13-acetate-Induced Psoriasis-Like Mouse Skin Lesions by
Yang G, Li S, Yang Y, Yuan L, Wang P et al.
Journal of agricultural and food chemistry, 2018
→
Chitosan-Glycolic Acid Gel Modification of Chloride Ion T...
Olga Zavyalova, Dominika Dąbrowska-Wisłocka, Konrad Misiura, Iga Hołyńska-Iwan
Molecules (Basel, Switzerland), 2023
→
Chitosan-Glycolic Acid Gel Modification of Chloride Ion T...
Olga Zavyalova, Dominika Dąbrowska-Wisłocka, Konrad Misiura, Iga Hołyńska-Iwan
Molecules (Basel, Switzerland), 2023
→
Chitosan-Glycolic Acid Gel Modification of Chloride Ion T...
Olga Zavyalova, Dominika Dąbrowska-Wisłocka, Konrad Misiura, Iga Hołyńska-Iwan
Molecules (Basel, Switzerland), 2023
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR