Phosphatidylglycerol
AKA “CHEBI:17517, PtdGro, phosphatidylglycerols, Glycerol Phosphoglycerides, RefChem:389200, Phosphoglycerides, Glycerol, 3(3-phosphatidyl-)glycerol, 3-(3-sn-phosphatidyl)glycerol, Epitope ID:135398”
Ingredient
Ingredient Facts
Phosphatidylglycerol
AKA: CHEBI:17517, PtdGro, Phosphatidylglycerols, Glycerol Phosphoglycerides, RefChem:389200, Phosphoglycerides, 3(3-phosphatidyl-)glycerol, 3-(3-sn-phosphatidyl)glycerol, Epitope ID:135398
Ingredient · Emulsifying · EWG: 1
Synthetic
Emulsifier
Skin Conditioner
Plant Oil
Clean
Phosphatidylglycerol is the phospholipid that conforms to the formula:(structure)where RCO- represents naturally occurring fatty acids
Formula
C8H23O7P
Mol. Weight
262.24
CAS #
92347-24-5
Form
Liquid
See origin →
Functions
Emulsifying
Forces oil and water to stay mixed instead of separating into layers. The unsung hero holding your lotion together.
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Stabilizes Emulsion
Skin Conditioning Miscellaneous
Skin Protecting
Emulsifier
Antioxidant Protection
Reduces Inflammation
Locks In Moisture
Improves skin feel
Shields skin from damage
Keeps product blended
Mixes oil and water
Traditional Use
A naturally occurring phospholipid component of cell membranes with no significant traditional use. Incorporated into modern cosmetics as a skin-conditioning and hydrating ingredient derived from plant sources.
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
EWG
1
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
45%
0%63%
Reg. Limit
FDA OTC limit: 45% (Skin Protectant). Also listed as anorectal protectant at 10-45% in 21 CFR 346.14 Source: FDA OTC Monograph, 21 CFR 347.10.
Regulatory Agencies
Alkylglycerol Derivatives, a New Class of Skin Penetration Modulators.
Bernal-Chávez SA, Pérez-Carreto LY, Nava-Arzaluz MG, Ganem-Rondero A
Molecules (Basel, Switzerland), 2017
Safety Assessment of Lecithin and Other Phosphoglycerides as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Lysophosphatidylglycerol
European Commission
EU Cosmetic Ingredient Database (CosIng)
Phosphatidylglycerol
European Commission
EU Cosmetic Ingredient Database (CosIng)
Phosphatidylglycerol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Phase Behavior of Polyglycerol Ester-Based Nanoemulsions.
Gan L, Cui D, Ali N, Zhang Q, Zhang D et al.
Journal of nanoscience and nanotechnology, 2021
Phase Behavior of Polyglycerol Ester-Based Nanoemulsions.
Gan L, Cui D, Ali N, Zhang Q, Zhang D et al.
Journal of nanoscience and nanotechnology, 2021
Phase Behavior of Polyglycerol Ester-Based Nanoemulsions.
Gan L, Cui D, Ali N, Zhang Q, Zhang D et al.
Journal of nanoscience and nanotechnology, 2021
Phase Behavior of Polyglycerol Ester-Based Nanoemulsions.
Gan L, Cui D, Ali N, Zhang Q, Zhang D et al.
Journal of nanoscience and nanotechnology, 2021
Phase Behavior of Polyglycerol Ester-Based Nanoemulsions.
Gan L, Cui D, Ali N, Zhang Q, Zhang D et al.
Journal of nanoscience and nanotechnology, 2021
Safety Assessment of Lecithin and Other Phosphoglycerides...
Wilbur Johnson, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler + 6 more
International journal of toxicology, 2020
Regioisomerism of triacylglycerols in lard, tallow, yolk, chicken skin, palm oil, palm olein, palm stearin, and a transesterified blend of palm steari
Kallio H, Yli-Jokipii K, Kurvinen JP, Sjövall O, Tahvonen R
Journal of agricultural and food chemistry, 2001
Regioisomerism of triacylglycerols in lard, tallow, yolk, chicken skin, palm oil, palm olein, palm stearin, and a transesterified blend of palm steari
Kallio H, Yli-Jokipii K, Kurvinen JP, Sjövall O, Tahvonen R
Journal of agricultural and food chemistry, 2001
Evaluation of additive effects of hydrolyzed jojoba (Simmondsia chinensis) esters and glycerol: a preliminary study.
Meyer J, Marshall B, Gacula M Jr, Rheins L
Journal of cosmetic dermatology, 2008
Evaluation of additive effects of hydrolyzed jojoba (Simmondsia chinensis) esters and glycerol: a preliminary study.
Meyer J, Marshall B, Gacula M Jr, Rheins L
Journal of cosmetic dermatology, 2008
Physicochemical properties and volatile formation mechanism of medium-chain triacylglycerols during heating.
Park S, Kim MJ, Lee JH
Journal of food science, 2022
Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function.
Pinto JR, Monteiro E Silva SA, Leonardi GR
International journal of cosmetic science, 2024
Polyglycerol fatty acid ester surfactant-based microemulsions for targeted delivery of ceramide AP into the stratum corneum: formulation, characterisa
Sahle FF, Metz H, Wohlrab J, Neubert RH
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2012
Starvation depresses acylglycerol biosynthesis in bovine subcutaneous but not intramuscular adipose tissue homogenates.
Smith SB, Lin KC, Wilson JJ, Lunt DK, Cross HR
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 1998
Targeting mitochondrial dysfunction in atopic dermatitis with trilinolein: A triacylglycerol from the medicinal plant Cannabis fructus.
Wang Y, Lu H, Cheng L, Guo W, Hu Y et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 2024
Tailoring the Stability of W/O/W Liquid Foundations: A Comparative Study of Polyglycerol-Based W/O Emulsifiers.
Zhu C, Zeng L, Xie Z, Luo G, Chung LH et al.
ACS omega, 2026
Tailoring the Stability of W/O/W Liquid Foundations: A Comparative Study of Polyglycerol-Based W/O Emulsifiers.
Zhu C, Zeng L, Xie Z, Luo G, Chung LH et al.
ACS omega, 2026
Tailoring the Stability of W/O/W Liquid Foundations: A Comparative Study of Polyglycerol-Based W/O Emulsifiers.
Zhu C, Zeng L, Xie Z, Luo G, Chung LH et al.
ACS omega, 2026
Tailoring the Stability of W/O/W Liquid Foundations: A Comparative Study of Polyglycerol-Based W/O Emulsifiers.
Zhu C, Zeng L, Xie Z, Luo G, Chung LH et al.
ACS omega, 2026
Tailoring the Stability of W/O/W Liquid Foundations: A Comparative Study of Polyglycerol-Based W/O Emulsifiers.
Zhu C, Zeng L, Xie Z, Luo G, Chung LH et al.
ACS omega, 2026
Tailoring the Stability of W/O/W Liquid Foundations: A Comparative Study of Polyglycerol-Based W/O Emulsifiers.
Zhu C, Zeng L, Xie Z, Luo G, Chung LH et al.
ACS omega, 2026
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR