Triisopalmitin
AKA “Isohexadecanoic acid, 1, 1', 1''-(1, 2, 3-propanetriyl) ester, RefChem:791875, Glycerol triisopalmitate, 68957-79-9, 3-bis(14-methylpentadecanoyloxy)propyl 14-methylpentadecanoate, 3-Propanetriyl triisohexadecanoate, Glyceryl triisopalmitate, Glycerol, triisopalmitate, EINECS 273-364-3”
Emollient
Ingredient Facts
Triisopalmitin
AKA: Isohexadecanoic acid, 1, 1', 1''-(1, 2, 3-propanetriyl) ester, RefChem:791875, Glycerol triisopalmitate, 68957-79-9, 3-bis(14-methylpentadecanoyloxy)propyl 14-methylpentadecanoate, 3-Propanetriyl triisohexadecanoate, Glyceryl triisopalmitate, Glycerol, Triisopalmitate, EINECS 273-364-3
Emollient · Emollient · EWG: 4
Synthetic
Emollient
Skin Conditioner
Not Clean
1,2,3-Propanetriyl triisohexadecanoate
Formula
C51H98O6
Mol. Weight
807.30
CAS #
68957-79-9
Form
Powder
State
Solid
See origin →
Functions
Skin Conditioning
A catch-all term for ingredients that improve how skin looks and feels — softer, smoother, more supple. The workhorse behind most moisturizers.
Emollient
Fills in the tiny cracks between skin cells to make everything feel smooth and soft. The "silky finish" ingredient.
Viscosity Controlling
Locks In Moisture
Traditional Use
A synthetic ester developed as a cosmetic emollient in modern skincare. Designed to provide conditioning and smooth texture similar to natural fatty acids.
Skin Types
●all-skin-types
Best For
Dryness
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Concentration Guide
45%
0%63%
Reg. Limit
FDA OTC limit: 45% (Skin Protectant). Also listed as anorectal protectant at 10-45% in 21 CFR 346.14 Source: FDA OTC Monograph, 21 CFR 347.10.
Regulatory Agencies
Alkylglycerol Derivatives, a New Class of Skin Penetration Modulators.
Bernal-Chávez SA, Pérez-Carreto LY, Nava-Arzaluz MG, Ganem-Rondero A
Molecules (Basel, Switzerland), 2017
Final Report on the Safety Assessment of Trilaurin, Triarachidin, Tribehenin, Tricaprin, Tricaprylin, Trierucin, Triheptanoin, Triheptylundecanoin, Triisononanoin, Triisopalmitin, Triisostearin, Trili
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
Lysophosphatidylglycerol
European Commission
EU Cosmetic Ingredient Database (CosIng)
Phosphatidylglycerol
European Commission
EU Cosmetic Ingredient Database (CosIng)
Triisopalmitin
European Commission
EU Cosmetic Ingredient Database (CosIng)
Phosphatidylglycerol
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
Phase Behavior of Polyglycerol Ester-Based Nanoemulsions.
Gan L, Cui D, Ali N, Zhang Q, Zhang D et al.
Journal of nanoscience and nanotechnology, 2021
Phase Behavior of Polyglycerol Ester-Based Nanoemulsions.
Gan L, Cui D, Ali N, Zhang Q, Zhang D et al.
Journal of nanoscience and nanotechnology, 2021
Phase Behavior of Polyglycerol Ester-Based Nanoemulsions.
Gan L, Cui D, Ali N, Zhang Q, Zhang D et al.
Journal of nanoscience and nanotechnology, 2021
Phase Behavior of Polyglycerol Ester-Based Nanoemulsions.
Gan L, Cui D, Ali N, Zhang Q, Zhang D et al.
Journal of nanoscience and nanotechnology, 2021
Phase Behavior of Polyglycerol Ester-Based Nanoemulsions.
Gan L, Cui D, Ali N, Zhang Q, Zhang D et al.
Journal of nanoscience and nanotechnology, 2021
Regioisomerism of triacylglycerols in lard, tallow, yolk, chicken skin, palm oil, palm olein, palm stearin, and a transesterified blend of palm steari
Kallio H, Yli-Jokipii K, Kurvinen JP, Sjövall O, Tahvonen R
Journal of agricultural and food chemistry, 2001
Regioisomerism of triacylglycerols in lard, tallow, yolk, chicken skin, palm oil, palm olein, palm stearin, and a transesterified blend of palm steari
Kallio H, Yli-Jokipii K, Kurvinen JP, Sjövall O, Tahvonen R
Journal of agricultural and food chemistry, 2001
Evaluation of additive effects of hydrolyzed jojoba (Simmondsia chinensis) esters and glycerol: a preliminary study.
Meyer J, Marshall B, Gacula M Jr, Rheins L
Journal of cosmetic dermatology, 2008
Evaluation of additive effects of hydrolyzed jojoba (Simmondsia chinensis) esters and glycerol: a preliminary study.
Meyer J, Marshall B, Gacula M Jr, Rheins L
Journal of cosmetic dermatology, 2008
Physicochemical properties and volatile formation mechanism of medium-chain triacylglycerols during heating.
Park S, Kim MJ, Lee JH
Journal of food science, 2022
Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function.
Pinto JR, Monteiro E Silva SA, Leonardi GR
International journal of cosmetic science, 2024
Polyglycerol fatty acid ester surfactant-based microemulsions for targeted delivery of ceramide AP into the stratum corneum: formulation, characterisa
Sahle FF, Metz H, Wohlrab J, Neubert RH
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2012
Starvation depresses acylglycerol biosynthesis in bovine subcutaneous but not intramuscular adipose tissue homogenates.
Smith SB, Lin KC, Wilson JJ, Lunt DK, Cross HR
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 1998
Targeting mitochondrial dysfunction in atopic dermatitis with trilinolein: A triacylglycerol from the medicinal plant Cannabis fructus.
Wang Y, Lu H, Cheng L, Guo W, Hu Y et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 2024
Tailoring the Stability of W/O/W Liquid Foundations: A Comparative Study of Polyglycerol-Based W/O Emulsifiers.
Zhu C, Zeng L, Xie Z, Luo G, Chung LH et al.
ACS omega, 2026
Tailoring the Stability of W/O/W Liquid Foundations: A Comparative Study of Polyglycerol-Based W/O Emulsifiers.
Zhu C, Zeng L, Xie Z, Luo G, Chung LH et al.
ACS omega, 2026
Tailoring the Stability of W/O/W Liquid Foundations: A Comparative Study of Polyglycerol-Based W/O Emulsifiers.
Zhu C, Zeng L, Xie Z, Luo G, Chung LH et al.
ACS omega, 2026
Tailoring the Stability of W/O/W Liquid Foundations: A Comparative Study of Polyglycerol-Based W/O Emulsifiers.
Zhu C, Zeng L, Xie Z, Luo G, Chung LH et al.
ACS omega, 2026
Tailoring the Stability of W/O/W Liquid Foundations: A Comparative Study of Polyglycerol-Based W/O Emulsifiers.
Zhu C, Zeng L, Xie Z, Luo G, Chung LH et al.
ACS omega, 2026
Tailoring the Stability of W/O/W Liquid Foundations: A Comparative Study of Polyglycerol-Based W/O Emulsifiers.
Zhu C, Zeng L, Xie Z, Luo G, Chung LH et al.
ACS omega, 2026
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR