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sorbic acid
AKA “110-44-1, (2E, 4E)-hexa-2, 4-dienoic acid, 2E, 4E-Hexadienoic acid, Sorbistat, Panosorb, 2-Propenylacrylic acid, Hexadienoic acid, trans, trans-Sorbic acid, 4E)-2, 4-Hexadienoic acid”
Acid
Ingredient Facts
Sorbic acid
AKA: 110-44-1, (2E, 4E)-hexa-2, 4-dienoic acid, 2E, 4E-Hexadienoic acid, Sorbistat, Panosorb, 2-Propenylacrylic acid, Hexadienoic acid, Trans, Trans-Sorbic acid, 4E)-2, 4-Hexadienoic acid
Acid · Preservative · EWG: 2
Synthetic
Preservative
Acid
Clean
(2E,4E)-2,4-Hexadienoic acid is a preservative for many foodstuffs. Generally used as K salt or (less frequently) as Ca salt. (2E,4E)-2,4-Hexadienoic acid is an antimicrobial agent against a wide variety of microorganisms, especially yeasts and moulds. (2E,4E)-2,4-Hexadienoic acid is a preservative action more efficient in acidic foods. Typical usage levels 500-2000 ppm (2E,4E)-2,4-Hexadienoic acid belongs to the family of Unsaturated Fatty Acids. These are fatty acids whose chain contains at least one CC double bond.
Solubility less than 1 mg/mL at 68 °F (NTP, 1992)
Formula
C6H8O2
Mol. Weight
112.13
CAS #
110-44-1
Form
Liquid
State
Sorbic acid appears as white powder or crystals. Melting point 134.5 °C. Slightly acidic and astringent taste with a faint odor.
See origin →
Functions
Preservative
Keeps your product from growing bacteria, mold, or yeast. Without these, that jar of cream becomes a petri dish in about a week.
Antioxidant
Antimicrobial
Improves Elasticity
Prevents microbial growth
Provides scent
Traditional Use
Discovered in the 1850s in the berries of mountain ash (Sorbus aucuparia). Adopted as a preservative in cosmetics and food in the early 20th century due to its antimicrobial properties and ability to inhibit mold and yeast growth.
Skin Types
●all-skin-types, gentle
Best For
General
Pregnancy & Breastfeeding Safe
Yes
EWG
2
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
ewg-2
medical-approval
pregnancy-nursing-safe
all-shades-safe
Phototoxicity Concern
Concentration Guide
0.6%
0%1%
Reg. Limit
EU regulatory limit: 0.6%. Source: EU Cosmetics Regulation (EC) 1223/2009, Annex V (Preservatives), Entry 4.
Regulatory Status
USA✔ permitted
EU✔ permitted
JAPAN✔ permitted
CANADA✔ permitted
Carnitine-Acylcarnitine Translocase Deficiency.
Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE et al.
, 1993
→
Carnitine-Acylcarnitine Translocase Deficiency.
Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE et al.
, 1993
→
Carnitine-Acylcarnitine Translocase Deficiency.
Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE et al.
, 1993
→
Carnitine-Acylcarnitine Translocase Deficiency.
Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE et al.
, 1993
→
Transcriptome Analysis of Jojoba (Simmondsia chinensis) during Seed Development and Liquid Wax Ester Biosynthesis.
Alotaibi SS, Elseehy MM, Aljuaid BS, El-Shehawi AM
Plants (Basel, Switzerland), 2020
→
Investigating transdermal delivery of vitamin D3.
Alsaqr A, Rasoully M, Musteata FM
AAPS PharmSciTech, 2015
→
Sexually transmitted diseases.
Bechtel MA, Trout W
Clinical obstetrics and gynecology, 2015
→
Deposition of plant lipids after single application of a lip care product determined by confocal raman spectroscopy, corneometry and transepidermal wa
Bielfeldt S, Blaak J, Laing S, Schleißinger M, Theiss C et al.
International journal of cosmetic science, 2019
→
Transforming Psoriasis Care: Probiotics and Prebiotics as Novel Therapeutic Approaches.
Buhaș MC, Candrea R, Gavrilaș LI, Miere D, Tătaru A et al.
International journal of molecular sciences, 2023
→
Mitochondrial carnitine-acylcarnitine translocase deficiency presenting as sudden neonatal death.
Chalmers RA, Stanley CA, English N, Wigglesworth JS
The Journal of pediatrics, 1997
→
Transdermal co-delivery of glucosamine sulfate and diacerein for the induction of chondroprotection in experimental osteoarthritis.
Chattopadhyay H, Auddy B, Sur T, Gupta M, Datta S
Drug delivery and translational research, 2020
→
Palmitoyl Acyltransferase Activity of ZDHHC13 Regulates Skin Barrier Development Partly by Controlling PADi3 and TGM1 Protein Stability.
Chen LY, Lin KR, Chen YJ, Chiang YJ, Ho KC et al.
The Journal of investigative dermatology, 2020
→
Biocompatible Potato-Starch Electrolyte-Based Coplanar Gate-Type Artificial Synaptic Transistors on Paper Substrates.
Choi HS, Lee YJ, Park H, Cho WJ
International journal of molecular sciences, 2022
→
Final Report on the Safety Assessment of Sorbic Acid and Potassium Sorbate
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
sorbic acid
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Lyotropic liquid crystal mesophases as transdermal delivery systems for lipophilic drugs: A comparative study.
de Araujo GRS, Azevedo Lima OV, Barreto Neujahr JP, Matos SS, de Souza TA et al.
International journal of pharmaceutics, 2023
→
Lyotropic liquid crystal mesophases as transdermal delivery systems for lipophilic drugs: A comparative study.
de Araujo GRS, Azevedo Lima OV, Barreto Neujahr JP, Matos SS, de Souza TA et al.
International journal of pharmaceutics, 2023
→
Aspartate signalling drives lung metastasis via alternative translation.
Doglioni G, Fernández-García J, Igelmann S, Altea-Manzano P, Blomme A et al.
Nature, 2025
→
epsilon-Aminocaproic acid esters as transdermal penetration enhancing agents.
Dolezal P, Hrabálek A, Semecký V
Pharmaceutical research, 1993
→
sorbic acid
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Comparative Study of Glyceryl Behenate or Polyoxyethylene 40 Stearate-Based Lipid Carriers for Trans-Resveratrol Delivery: Development, Characterizati
Fachinetti N, Rigon RB, Eloy JO, Sato MR, Dos Santos KC et al.
AAPS PharmSciTech, 2018
→
Comparative Study of Glyceryl Behenate or Polyoxyethylene 40 Stearate-Based Lipid Carriers for Trans-Resveratrol Delivery: Development, Characterizati
Fachinetti N, Rigon RB, Eloy JO, Sato MR, Dos Santos KC et al.
AAPS PharmSciTech, 2018
→
Development of an Auraptene-Loaded Transdermal Formulation Using Non-ionic Sugar Ester Surfactants.
Flores KA, Okada A, Arce F Jr, See GL, Itakura S et al.
Chemical & pharmaceutical bulletin, 2024
→
Potential application of novel liquid crystal nanoparticles of isostearyl glyceryl ether for transdermal delivery of 4-biphenyl acetic acid.
Fujii MY, Asakawa Y, Fukami T
International journal of pharmaceutics, 2020
→
Transdermal permeability of N-acetyl-D-glucosamine.
Garner ST Jr, Israel BJ, Achmed H, Capomacchia AC, Abney T et al.
Pharmaceutical development and technology, 2007
→
Growth inhibition of human melanoma tumor cells by the combination of sodium phenylacetate (NaPA) and substituted dextrans and one NaPA-dextran conjug
Gervelas C, Avramoglou T, Crépin M, Jozefonvicz J
Anti-cancer drugs, 2002
→
Dissolving microarray patches for transdermal delivery of risperidone for schizophrenia management.
Ghanma R, Naser YA, Kurnia Anjani Q, Hidayat Bin Sabri A, Hutton ARJ et al.
International journal of pharmaceutics, 2024
→
Transdermal delivery of ondansetron hydrochloride: effects of vehicles and penetration enhancers.
Gwak HS, Oh IS, Chun IK
Drug development and industrial pharmacy, 2004
→
Transdermal Delivery of Indirubin-Loaded Microemulsion Gel: Preparation, Characterization and Anti-Psoriatic Activity.
He E, Li H, Li X, Wu X, Lei K et al.
International journal of molecular sciences, 2022
→
Methyl-trans-2-butenoate
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
trans-2-Heptenal
Health Canada
Health Canada Cosmetic Ingredient Hotlist
→
Preparation, evaluation, and NMR characterization of vinpocetine microemulsion for transdermal delivery.
Hua L, Weisan P, Jiayu L, Ying Z
Drug development and industrial pharmacy, 2004
→
Regioisomerism of triacylglycerols in lard, tallow, yolk, chicken skin, palm oil, palm olein, palm stearin, and a transesterified blend of palm steari
Kallio H, Yli-Jokipii K, Kurvinen JP, Sjövall O, Tahvonen R
Journal of agricultural and food chemistry, 2001
→
Regioisomerism of triacylglycerols in lard, tallow, yolk, chicken skin, palm oil, palm olein, palm stearin, and a transesterified blend of palm steari
Kallio H, Yli-Jokipii K, Kurvinen JP, Sjövall O, Tahvonen R
Journal of agricultural and food chemistry, 2001
→
Dietary intervention of prebiotic partially hydrolyzed guar gum improves skin viscoelasticity, stratum corneum hydration, and reduction of trans-epide
Kapoor MP, Abe A, Morishima S, Nakajima A, Ozeki M et al.
Journal of clinical biochemistry and nutrition, 2025
→
Dietary intervention of prebiotic partially hydrolyzed guar gum improves skin viscoelasticity, stratum corneum hydration, and reduction of trans-epide
Kapoor MP, Abe A, Morishima S, Nakajima A, Ozeki M et al.
Journal of clinical biochemistry and nutrition, 2025
→
Transdermal delivery of physostigmine: effects of enhancers and pressure-sensitive adhesives.
Kim JH, Lee CH, Choi HK
Drug development and industrial pharmacy, 2002
→
Transdermal delivery of physostigmine: effects of enhancers and pressure-sensitive adhesives.
Kim JH, Lee CH, Choi HK
Drug development and industrial pharmacy, 2002
→
Transdermal delivery of physostigmine: effects of enhancers and pressure-sensitive adhesives.
Kim JH, Lee CH, Choi HK
Drug development and industrial pharmacy, 2002
→
Microemulsions as transdermal drug delivery vehicles.
Kogan A, Garti N
Advances in colloid and interface science, 2006
→
Microemulsions as transdermal drug delivery vehicles.
Kogan A, Garti N
Advances in colloid and interface science, 2006
→
Microemulsions as transdermal drug delivery vehicles.
Kogan A, Garti N
Advances in colloid and interface science, 2006
→
Studies on the transdermal delivery of nimodipine from a menthol-based TTS in human volunteers.
Krishnaiah YS, Bhaskar P
Current drug delivery, 2004
→
Effect of the type of lubricant on the characteristics of orally disintegrating tablets manufactured using the phase transition of sugar alcohol.
Kuno Y, Kojima M, Nakagami H, Yonemochi E, Terada K
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2008
→
Ethyl Cellulose and Hydroxypropyl Methyl Cellulose Blended Methotrexate-Loaded Transdermal Patches: In Vitro and Ex Vivo.
Latif MS, Azad AK, Nawaz A, Rashid SA, Rahman MH et al.
Polymers, 2021
→
Development of long-acting riluzole transdermal patch against amyotrophic lateral sclerosis: Mechanistic insights into polyglyceryl-3 dioleate-enhance
Liu Y, Chen G, Li M, Li M, Xie D et al.
International journal of pharmaceutics: X, 2025
→
Using Microemulsion as Carrier for Drug Transdermal Delivery: The Effect of Surfactants and Cosurfactants.
Lu IJ, Fu YS, Chang WY, Wu PC
Current pharmaceutical design, 2019
→
Transdermal delivery of paeonol using cubic gel and microemulsion gel.
Luo M, Shen Q, Chen J
International journal of nanomedicine, 2011
→
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Luo Y, Xie C, Brocker CN, Fan J, Wu X et al.
Gastroenterology, 2019
→
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Luo Y, Xie C, Brocker CN, Fan J, Wu X et al.
Gastroenterology, 2019
→
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Luo Y, Xie C, Brocker CN, Fan J, Wu X et al.
Gastroenterology, 2019
→
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Luo Y, Xie C, Brocker CN, Fan J, Wu X et al.
Gastroenterology, 2019
→
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Luo Y, Xie C, Brocker CN, Fan J, Wu X et al.
Gastroenterology, 2019
→
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Luo Y, Xie C, Brocker CN, Fan J, Wu X et al.
Gastroenterology, 2019
→
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Luo Y, Xie C, Brocker CN, Fan J, Wu X et al.
Gastroenterology, 2019
→
Transdermal absorption of natural progesterone from alcoholic gel formulations with hydrophilic surfactant.
Matsui R, Ueda O, Uchida S, Namiki N
Drug development and industrial pharmacy, 2015
→
Hollow microneedle-based sensor for multiplexed transdermal electrochemical sensing.
Miller PR, Skoog SA, Edwards TL, Wheeler DR, Xiao X et al.
Journal of visualized experiments : JoVE, 2012
→
Cremophor RH40-PEG 400 microemulsions as transdermal drug delivery carrier for ketoprofen.
Ngawhirunpat T, Worachun N, Opanasopit P, Rojanarata T, Panomsuk S
Pharmaceutical development and technology, 2013
→
MCT1 lactate transporter blockade re-invigorates anti-tumor immunity through metabolic rewiring of dendritic cells in melanoma.
Niveau C, Cettour-Cave M, Mouret S, Sosa Cuevas E, Pezet M et al.
Nature communications, 2025
→
Effects of vehicles and enhancers on transdermal delivery of melatonin.
Oh HJ, Oh YK, Kim CK
International journal of pharmaceutics, 2001
→
Development of novel double-decker microneedle patches for transcutaneous vaccine delivery.
Ono A, Azukizawa H, Ito S, Nakamura Y, Asada H et al.
International journal of pharmaceutics, 2017
→
Orphan nuclear receptor NR4A1 regulates transforming grow...
Katrin Palumbo-Zerr, Pawel Zerr, Alfiya Distler, Judith Fliehr, Rossella Mancuso, Jingang Huang + 11 more
Nature medicine, 2015
→
Cyclodextrin glucanotransferase: fundamentals and biotechnological implications.
Pardhi DS, Rabadiya KJ, Panchal RR, Raval VH, Joshi RG et al.
Applied microbiology and biotechnology, 2023
→
Grape berry transpiration influences ripening and must composition in cv. Tempranillo (Vitis vinifera L.).
Pascual I, Antolín MC, Goicoechea N, Irigoyen JJ, Morales F
Physiologia plantarum, 2022
→
Self-Assembled Structure of α-Isostearyl Glyceryl Ether Affects Skin Permeability-a Lamellar with 70-nm Spaces and L3 Phase Enhanced the Transdermal D
Sano T, Okada A, Kawasaki K, Kume T, Fukui M et al.
AAPS PharmSciTech, 2022
→
Self-Assembled Structure of α-Isostearyl Glyceryl Ether Affects Skin Permeability-a Lamellar with 70-nm Spaces and L3 Phase Enhanced the Transdermal D
Sano T, Okada A, Kawasaki K, Kume T, Fukui M et al.
AAPS PharmSciTech, 2022
→
Liposomes and transferosomes in the delivery of papain fo...
Rachana Sapkota, Daniel J Munt, Anthony E Kincaid, Alekha K Dash
PloS one, 2023
→
Liposomes and transferosomes in the delivery of papain fo...
Rachana Sapkota, Daniel J Munt, Anthony E Kincaid, Alekha K Dash
PloS one, 2023
→
Development of antimigraine transdermal delivery systems of pizotifen malate.
Serna-Jiménez CE, del Rio-Sancho S, Calatayud-Pascual MA, Balaguer-Fernández C, Femenía-Font A et al.
International journal of pharmaceutics, 2015
→
Liver transplantation in the management of porphyria.
Singal AK, Parker C, Bowden C, Thapar M, Liu L et al.
Hepatology (Baltimore, Md.), 2014
→
Transdermal application of steroid hormones for contraception.
Sitruk-Ware R
The Journal of steroid biochemistry and molecular biology, 1995
→
Microemulsions formed by PPG-5-CETETH-20 at low concentrations for transdermal delivery of nifedipine: Structural and in vitro study.
Souza de Araujo GR, Mendonça da Cruz Macieira G, Xavier de Oliveira D, Santos Matos S, Nery Dos Santos Q et al.
Colloids and surfaces. B, Biointerfaces, 2022
→
Microemulsions formed by PPG-5-CETETH-20 at low concentrations for transdermal delivery of nifedipine: Structural and in vitro study.
Souza de Araujo GR, Mendonça da Cruz Macieira G, Xavier de Oliveira D, Santos Matos S, Nery Dos Santos Q et al.
Colloids and surfaces. B, Biointerfaces, 2022
→
Aloe vera leaf mucilage and lemon oil as potential penetration-enhancing agents to increase lornoxicam transdermal administration using nano vesicular
Subramaniyan G, Rubina S, Ramana BV, Stanley AM, Srinivasan D
Pakistan journal of pharmaceutical sciences, 2024
→
Advancements in chain elongation technology: Transforming lactic acid into caproic acid for sustainable biochemical production.
Suo M, Liu L, Fan H, Li N, Pan H et al.
Bioresource technology, 2025
→
Novel Vesicular Bilosomal Delivery Systems for Dermal/Transdermal Applications.
Suvarna V, Mallya R, Deshmukh K, Sawant B, Khan TA et al.
Current drug delivery, 2024
→
Novel Vesicular Bilosomal Delivery Systems for Dermal/Transdermal Applications.
Suvarna V, Mallya R, Deshmukh K, Sawant B, Khan TA et al.
Current drug delivery, 2024
→
Novel Vesicular Bilosomal Delivery Systems for Dermal/Transdermal Applications.
Suvarna V, Mallya R, Deshmukh K, Sawant B, Khan TA et al.
Current drug delivery, 2024
→
Novel Vesicular Bilosomal Delivery Systems for Dermal/Transdermal Applications.
Suvarna V, Mallya R, Deshmukh K, Sawant B, Khan TA et al.
Current drug delivery, 2024
→
The biotechnology (genetic transformation and molecular biology) of Bixa orellana L. (achiote).
Teixeira da Silva JA, Dobránszki J, Rivera-Madrid R
Planta, 2018
→
Highly galloylated tannin fractions from witch hazel (Hamamelis virginiana) bark: electron transfer capacity, in vitro antioxidant activity, and effec
Touriño S, Lizárraga D, Carreras A, Lorenzo S, Ugartondo V et al.
Chemical research in toxicology, 2008
→
Transdermal delivery of levosimendan.
Valjakka-Koskela R, Hirvonen J, Mönkkönen J, Kiesvaara J, Antila S et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2000
→
Semisynthetic Derivative of Artemisia annua-Loaded Transdermal Bioadhesive for the Treatment of Uncomplicated Malaria Caused by Plasmodium falciparum
Volpe Zanutto F, McAlister E, Marucci Pereira Tangerina M, Fonseca-Santos B, Costa Salles TH et al.
Journal of pharmaceutical sciences, 2019
→
Bioactive Glycyrrhizic Acid Ionic Liquid Self-Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti-Photoaging Signal Peptides.
Wang Z, Liu J, Chen Q, Wu Y, Li Y et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025
→
Bioactive Glycyrrhizic Acid Ionic Liquid Self-Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti-Photoaging Signal Peptides.
Wang Z, Liu J, Chen Q, Wu Y, Li Y et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025
→
Triclosan exposure, transformation, and human health effects.
Weatherly LM, Gosse JA
Journal of toxicology and environmental health. Part B, Critical reviews, 2017
→
Bioinspired Bilayer Nanofibrous Membrane with Unidirectional Water Transport, Antimicrobial Properties, Antioxidant Capacity, and pH-Responsive Epigal
Xia Z, Shang S, Zhang J, Ding Z, Li X et al.
Langmuir : the ACS journal of surfaces and colloids, 2025
→
Verified Jun 2026
Data: PubChem · CosIng · EWG · CIR