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Vitis vinifera (Grape) leaf/seed/skin extract
AKA “Grape Leaf/Seed/Skin Extract”
Extract
Ingredient Facts
Vitis vinifera (Grape) leaf/seed/skin extract
AKA: Grape Leaf/Seed/Skin Extract
Extract · Antioxidant · EWG: 4
Plant-Derived
Antioxidant
Extract
Not Clean
Vitis Vinifera (Grape) Leaf/Seed/Skin Extract is a cosmetic ingredient used as antioxidant. Assessed as safe by the CIR.
Family
Vitaceae (Grape family)
Plant Part
Leaf
Lifeform
Liana
Climate
Temperate
CAS #
85594-37-2 / 84929-27-1
Form
Liquid
See origin →
Functions
Antioxidant
Fights free radicals — the unstable molecules from UV, pollution, and stress that break down collagen and cause premature aging.
Anti-Aging Benefits
Reduces Inflammation
Fights free radical damage
Traditional Use
This composite extract leverages the antioxidant and polyphenol-rich compounds from multiple grape parts, reflecting modern extraction techniques rather than a single traditional use.
Skin Types
●all-skin-types
Best For
Sun Damage
Pregnancy & Breastfeeding Safe
Yes
EWG
4
CIR
Safe as used
Pregnancy
Yes
CIR Safety Findings
Not a Sensitizer
medical-approval
all-shades-safe
Regulatory Status
USA✔ permitted
EU⚠ restricted
JAPAN⚠ restricted
CANADA⚠ restricted
Cocoa and Grape Seed Byproducts as a Source of Antioxidant and Anti-Inflammatory Proanthocyanidins.
Cádiz-Gurrea ML, Borrás-Linares I, Lozano-Sánchez J, Joven J, Fernández-Arroyo S et al.
International journal of molecular sciences, 2017
→
Grape anaphylaxis.
Caiaffa MF, Tursi A, Macchia L
Journal of investigational allergology & clinical immunology, 2003
→
Grape anaphylaxis.
Caiaffa MF, Tursi A, Macchia L
Journal of investigational allergology & clinical immunology, 2003
→
Diospyros lotus leaf and grapefruit stem extract synergistically ameliorate atopic dermatitis-like skin lesion in mice by suppressing infiltration of
Cho BO, Che DN, Yin HH, Shin JY, Jang SI
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017
→
Safety Assessment of <I>Vitis vinifera</I>-Grape-Derived Ingredients as Used in Cosmetics
Cosmetic Ingredient Review (CIR) Expert Panel
International Journal of Toxicology
→
Citrus Grandis (Grapefruit)
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Grandis (Grapefruit) Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Grandis (Grapefruit) Fruit Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Grandis (Grapefruit) Fruit Water
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Grandis (Grapefruit) Fruit/Peel Water
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Grandis (Grapefruit) Juice
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Grandis (Grapefruit) Leaf Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Grandis (Grapefruit) Peel
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
citrus grandis (grapefruit) peel extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Grandis (Grapefruit) Peel Oil
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Grandis (Grapefruit) Peel Powder
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Grandis (Grapefruit) Seed Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Grandis (Grapefruit) Seed Oil
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Grandis (Grapefruit) Seed Oil Unsaponifiables
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Paradisi (Grapefruit) Fruit Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Paradisi (Grapefruit) Fruit Water
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Paradisi (Grapefruit) Juice
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Paradisi (Grapefruit) Peel Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Paradisi (Grapefruit) Peel Oil
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Paradisi (Grapefruit) Seed Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Paradisi (Grapefruit) Seed Oil
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Grape Seed Oil PEG-8 Esters
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydrogenated Grapefruit Seed Oil
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydrogenated Grapefruit Seed Oil Unsaponifiables
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydrogenated Grapeseed Oil
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydrolyzed Grape Fruit
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Hydrolyzed Grape Skin
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Sodium Grapeseedate
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape)
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Bud Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Flower Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Fruit Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Fruit Powder
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Fruit Water
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Juice
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Juice Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Leaf Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Leaf Oil
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Leaf Water
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Leaf/Seed/Skin Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Root Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Seed
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis vinifera (grape) seed extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Seed Oil
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Seed Powder
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Shoot Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Skin Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Skin Powder
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Vine Extract
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Vitis Vinifera (Grape) Vine Sap
European Commission
EU Cosmetic Ingredient Database (CosIng)
→
Citrus Grandis (Grapefruit)
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Citrus Grandis (Grapefruit) Fruit Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Citrus Grandis (Grapefruit) Fruit Water
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Citrus Grandis (Grapefruit) Juice
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Citrus Grandis (Grapefruit) Leaf Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Citrus Grandis (Grapefruit) Peel
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
citrus grandis (grapefruit) peel extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Citrus Grandis (Grapefruit) Peel Oil
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Citrus Grandis (Grapefruit) Seed Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Citrus Grandis (Grapefruit) Seed Oil
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Citrus Paradisi (Grapefruit) Fruit Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Citrus Paradisi (Grapefruit) Juice
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Citrus paradisi (grapefruit) oil
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Citrus Paradisi (Grapefruit) Peel Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Citrus Paradisi (Grapefruit) Peel Oil
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Citrus Paradisi (Grapefruit) Seed Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Citrus Paradisi (Grapefruit) Seed Oil
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Hydrogenated Grapeseed Oil
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Vitis Vinifera (Grape)
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Vitis Vinifera (Grape) Fruit Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Vitis Vinifera (Grape) Fruit Water
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Vitis Vinifera (Grape) Juice
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Vitis Vinifera (Grape) Juice Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Vitis Vinifera (Grape) Leaf Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Vitis Vinifera (Grape) Leaf Oil
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Vitis Vinifera (Grape) Root Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Vitis Vinifera (Grape) Seed
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Vitis vinifera (grape) seed extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Vitis Vinifera (Grape) Seed Oil
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Vitis Vinifera (Grape) Seed Powder
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Vitis Vinifera (Grape) Skin Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Vitis Vinifera (Grape) Skin Powder
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Vitis Vinifera (Grape) Vine Extract
Environmental Working Group (EWG)
EWG Skin Deep Cosmetics Database
→
Preharvest Fungicide, Potassium Sorbate, or Chitosan Use on Quality and Storage Decay of Table Grapes.
Feliziani E, Smilanick JL, Margosan DA, Mansour MF, Romanazzi G et al.
Plant disease, 2013
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Antimicrobial effectiveness of grape seed extract against Enterococcus faecalis biofilm: A Confocal Laser Scanning Microscopy analysis.
Fiallos NM, Cecchin D, de Lima CO, Hirata R Jr, Silva EJNL et al.
Australian endodontic journal : the journal of the Australian Society of Endodontology Inc, 2020
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Safety assessment of Vitis vinifera (grape)-derived ingredients as used in cosmetics.
Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2014
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Safety assessment of Vitis vinifera (grape)-derived ingredients as used in cosmetics.
Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al.
International journal of toxicology, 2014
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Development and validation of an HPLC/UV/MS method for simultaneous determination of 18 preservatives in grapefruit seed extract.
Ganzera M, Aberham A, Stuppner H
Journal of agricultural and food chemistry, 2006
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Development and validation of an HPLC/UV/MS method for simultaneous determination of 18 preservatives in grapefruit seed extract.
Ganzera M, Aberham A, Stuppner H
Journal of agricultural and food chemistry, 2006
→
Outgoing and potential trends of composition, health benefits, juice production and waste management of the multi-faceted Grapefruit Citrus Χ paradisi
Khalil MNA, Farghal HH, Farag MA
Critical reviews in food science and nutrition, 2022
→
Outgoing and potential trends of composition, health benefits, juice production and waste management of the multi-faceted Grapefruit Citrus Χ paradisi
Khalil MNA, Farghal HH, Farag MA
Critical reviews in food science and nutrition, 2022
→
Outgoing and potential trends of composition, health benefits, juice production and waste management of the multi-faceted Grapefruit Citrus Χ paradisi
Khalil MNA, Farghal HH, Farag MA
Critical reviews in food science and nutrition, 2022
→
Outgoing and potential trends of composition, health benefits, juice production and waste management of the multi-faceted Grapefruit Citrus Χ paradisi
Khalil MNA, Farghal HH, Farag MA
Critical reviews in food science and nutrition, 2022
→
Outgoing and potential trends of composition, health benefits, juice production and waste management of the multi-faceted Grapefruit Citrus Χ paradisi
Khalil MNA, Farghal HH, Farag MA
Critical reviews in food science and nutrition, 2022
→
Development of a comprehensive analytical method for furanocoumarins in grapefruit and their metabolites in plasma and urine using UPLC-MS/MS: a preli
Lee SG, Kim K, Vance TM, Perkins C, Provatas A et al.
International journal of food sciences and nutrition, 2016
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Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry.
Martin ME, Grao-Cruces E, Millan-Linares MC, Montserrat-de la Paz S
Foods (Basel, Switzerland), 2020
→
Review of the Pharmacological Effects of Vitis vinifera (Grape) and its Bioactive Constituents: An Update.
Nassiri-Asl M, Hosseinzadeh H
Phytotherapy research : PTR, 2016
→
Grape Seed Oil Microemulsion for Improved Skin Delivery o...
Marianne A P C Nogueira, Camila O Cardoso, Lucas F F Albuquerque, Marcilio Cunha-Filho, Tais Gratieri, Guilherme M Gelfuso
AAPS PharmSciTech, 2025
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Grape Seed Oil Microemulsion for Improved Skin Delivery o...
Marianne A P C Nogueira, Camila O Cardoso, Lucas F F Albuquerque, Marcilio Cunha-Filho, Tais Gratieri, Guilherme M Gelfuso
AAPS PharmSciTech, 2025
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Grape berry transpiration influences ripening and must composition in cv. Tempranillo (Vitis vinifera L.).
Pascual I, Antolín MC, Goicoechea N, Irigoyen JJ, Morales F
Physiologia plantarum, 2022
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Antioxidant capacity, phenolic content, and profiling of phenolic compounds in the seeds, skin, and pulp of Vitis rotundifolia (Muscadine Grapes) As d
Sandhu AK, Gu L
Journal of agricultural and food chemistry, 2010
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Shoot Cultures of Vitis vinifera (Vine Grape) Different Cultivars as a Promising Innovative Cosmetic Raw Material-Phytochemical Profiling, Antioxidant
Sharafan M, Malinowska MA, Kubicz M, Kubica P, Gémin MP et al.
Molecules (Basel, Switzerland), 2023
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Vitis vinifera (Vine Grape) as a Valuable Cosmetic Raw Material.
Sharafan M, Malinowska MA, Ekiert H, Kwaśniak B, Sikora E et al.
Pharmaceutics, 2023
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Vitis vinifera (Vine Grape) as a Valuable Cosmetic Raw Material.
Sharafan M, Malinowska MA, Ekiert H, Kwaśniak B, Sikora E et al.
Pharmaceutics, 2023
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Absorbent bioactive aerogels based on germinated wheat starch and grape skin extract.
Silva FT, Fonseca LM, Bruni GP, Crizel RL, Oliveira EG et al.
International journal of biological macromolecules, 2023
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Absorbent bioactive aerogels based on germinated wheat starch and grape skin extract.
Silva FT, Fonseca LM, Bruni GP, Crizel RL, Oliveira EG et al.
International journal of biological macromolecules, 2023
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Effects of antioxidant capacity-based dietary replacement of vitamin E with commercial products containing grape skin-green tea extracts or hydrolyzed
Simoni M, Danese T, Mezzasalma N, Goi A, Pitino R et al.
Frontiers in veterinary science, 2025
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Vitis vinifera L. grape skin extract activates the insulin-signalling cascade and reduces hyperglycaemia in alloxan-induced diabetic mice.
Soares de Moura R, da Costa GF, Moreira AS, Queiroz EF, Moreira DD et al.
The Journal of pharmacy and pharmacology, 2012
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Effects of Leaf Removal and Applied Water on Flavonoid Accumulation in Grapevine (Vitis vinifera L. cv. Merlot) Berry in a Hot Climate.
Yu R, Cook MG, Yacco RS, Watrelot AA, Gambetta G et al.
Journal of agricultural and food chemistry, 2016
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Changes of Anthocyanin Component Biosynthesis in 'Summer Black' Grape Berries after the Red Flesh Mutation Occurred.
Zhang K, Liu Z, Guan L, Zheng T, Jiu S et al.
Journal of agricultural and food chemistry, 2018
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Protective Effects of Grapefruit Essential Oil against Staphylococcus Aureus-Induced Inflammation and Cell Damage in Human Epidermal Keratinocytes.
Zhang X, Xu H, Hua J, Zhu Z, Wang M
Chemistry & biodiversity, 2022
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Following the compositional changes of fresh grape skin cell walls during the fermentation process in the presence and absence of maceration enzymes.
Zietsman AJ, Moore JP, Fangel JU, Willats WG, Trygg J et al.
Journal of agricultural and food chemistry, 2015
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Verified Jun 2026
Data: Kew POWO · CosIng · EWG · CIR